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This study will evaluate how a common dietary sugar (fructose) raises blood fats (triglycerides). We will determine whether the production of fat from fructose is higher in dialysis patients compared to healthy volunteers. Dialysis patients have high levels of hormone-like substances called cytokines that may increase blood fats. The results will help set better guidelines for diets for the general population and patients with kidney disease who are at high risk for heart attack and stroke.
There will be one or two outpatient screening visit(s) and a one-week (6 nights) stay at the Rockefeller University Hospital.
Full description
Fifteen hemodialysis patients and 15 healthy volunteers will be studied.
Outpatient screening visit(s): consent, fasting blood and urine analysis, a physical exam, an EKG and a 2-hour oral glucose tolerance test to screen for diabetes.
Inpatient admission:
At the end of the infusion, a sweet drink (fructose in 1 ounce of water) will be given orally every half hour for 6 hours.
• Two small samples of fat taken right below the skin will be obtained after injection of a small amount of numbing medicine into the abdominal and gluteal regions.
Dialysis patients will receive their usual dialysis at The Rogosin Institute Manhattan, Brooklyn or Queens Dialysis Units.
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Inclusion criteria
Exclusion criteria
Healthy Controls:
Inclusion Criteria
Male and females, 18-75 years of age 2. LDL <160 mg/dl, HDL-C >30 mg/dl, TG <250 mg/dl 3. Willing and able to stop ASA, NSAID, fish oil, psyllium, other vitamins/supplements for 1 week prior to study until completion of study 4. Willing and able to sign an informed consent 5. Willing to refrain from participation in an investigational drug study for the duration of the study Exclusion Criteria
Systemic illnesses, including diabetes (FBS >126 twice or abnormal OGTT), cardiovascular disease, hepatitis, endocrine disease, HIV infection.
Prescription medications, including contraceptives.
Acute febrile illness within 1 month of admission.
BMI >35 (markedly obese) or>10% below maximum weight.
Weight change of >10% usual weight in the previous 6 months.
Blood pressure >140/90.
HB <11 female, <12 male.
CRP >5.0 on 2 occasions. 7/15/2008 Form version 6/13/2005 #LHU-0471-0407 Page 9of 16f
Abuse of ethanol (greater than 2 drinks/day) or illicit drugs.
Cigarette smoking >1/2 pack/day.
Unusual diet or extreme physical activity (e.g. marathon runner).
If female, pregnant or breast feeding.
Participation in a study of an investigational drug during the 30 days preceding the start of the screening period.
Have any other condition, which in the opinion of the investigator, should prohibit the participation in the study.
Primary purpose
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Interventional model
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30 participants in 2 patient groups
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Data sourced from clinicaltrials.gov
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