The Effect of General Anesthesia on the Middle Ear Pressure

Trakya University

Status: Completed

Conditions: Ear Deformities, Acquired

Treatments: Drug: Sevoflurane; Drug: desflurane,

Study type: Interventional

Funder types: Other

Identifiers

NCT03100604

2013/136

Details and patient eligibility

About

The investigators aimed to examine the effect of sevoflurane and desflurane, agents used in patients who do not have any ear pathology and undergo surgery under general anesthesia, on the MEP.

Full description

Studies reported that inhalation agents are more likely to have impacts on the middle ear pressure compared to intravenous anesthetic agents. Despite numerous studies comparing the effects of inhalation agents on the middle ear pressure, this is the first clinical trial in which end tidal carbon dioxide and effects of sevoflurane and desflurane, along with other anesthetic analgesic agents used, on the middle ear pressure were compared. Our purpose in this study was to investigate the effect of sevoflurane and desflurane, inhalation agents used in patients who do not have any ear pathology and undergo non-ear surgery under general anesthesia, on the middle ear pressure.

Enrollment: 50 patients

Sex: All

Ages: 20 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• (ASA) II-III physical status
• elective inguinal hernia
• lower extremity surgery
• general anesthesia
• supine position

Exclusion criteria

• nasal septum,
• adenotonsillar hypertrophy,
• perforated tympanic membrane,
• middle ear pathology
• receive medications for middle ear pressure .

Trial design

Primary purpose: Treatment

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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50 participants in 2 patient groups

sevoflurane 2%, 1 MAC

Experimental group

Description:

Maintenance of anesthesia was provided with 2% sevoflurane in S Group, and 6-9% desflurane in D Group, with 50% air /oxygen mixture and fresh gas flow at 4 l/min in both groups.

Treatment:

Drug: Sevoflurane

Desfluran 6-9% 1MAC

Experimental group

Description:

Maintenance of anesthesia was provided with 2% sevoflurane in S Group, and 6-9% desflurane in D Group, with 50% air /oxygen mixture and fresh gas flow at 4 l/min in both groups.

Treatment:

Drug: desflurane,