The Effect of Genetic Polymorphism on Interactions of Clopidogrel and Cilostazol in Healthy Volunteers

Inje University

Status: Completed

Conditions: Interaction

Treatments: Drug: Clopidogrel/Cilostazol; Drug: Clopidogrel; Drug: Cilostazol

Study type: Interventional

Funder types: Other

Identifiers

NCT01482117

10-105

Details and patient eligibility

About

The aim of this study is to investigate the effects of genetic polymorphisms on pharmacokinetic and pharmacodynamic interactions of clopidogrel and cilostazol in Korean healthy adult volunteers.

Enrollment: 28 patients

Sex: Male

Ages: 20 to 45 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy male subject whose CYP2C19 genotype was determined

Exclusion criteria

• Subject who has abnormal laboratory test results

Trial design

Primary purpose: Health Services Research

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: None (Open label)

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28 participants in 3 patient groups

Clopidogrel

Active Comparator group

Description:

single oral administration of 300mg of clopidogrel

Treatment:

Drug: Cilostazol

Drug: Clopidogrel

Drug: Clopidogrel/Cilostazol

Cilostarole

Active Comparator group

Description:

single oral administration of 100mg of cilostazole

Treatment:

Drug: Cilostazol

Drug: Clopidogrel

Drug: Clopidogrel/Cilostazol

Clopidogrel/Cilostazol

Active Comparator group

Description:

single oral administration of 300mg clopidogrel and 100mg cilostazol

Treatment:

Drug: Cilostazol

Drug: Clopidogrel

Drug: Clopidogrel/Cilostazol