The Effect of Glycaemic Index Variation on Blood Glucose and Mood in Healthy Participants Across the Day

Matthew Grout

Status: Completed

Conditions: Mood; Glucose, High Blood; Diet Modification; Glucose, Low Blood

Treatments: Dietary Supplement: High Glycaemic Diet; Dietary Supplement: Low Glycaemic Diet

Study type: Interventional

Funder types: Other

Identifiers

NCT03344185

2016-032-DL

Details and patient eligibility

About

This study provided 24 healthy subjects with two diets that varied in their glycaemic index values. One condition was a low GI diet, whilst the other was a high GI diet. Glucose concentrations and mood were measured throughout each test day.

Full description

Therefore, the aim of this study is to feed to participants meals which differing in their glycaemic index across the course of a day, and thus produce different glycaemic responses. The outcome variables will be blood glucose levels and subjective mood. The purpose of this study is to identify the appropriate times (according to glycaemic response) at which cognitive functioning should be tested. Importantly, this study is also the first step to characterizing glycaemic and cognitive profiles associated with food consumption over a whole day (breakfast, lunch, snack) rather than just one meal (e.g. breakfast), ranging from the most favourable (stable glucose regulation) to the least favourable (variability; many peaks and troughs).

Enrollment: 24 patients

Sex: All

Ages: 18 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Aged between 18 and 65 years of age.
• Willing to participate in the entire study (signed informed consent required)
• Subjects will be eligible for the study if male or female (not pregnant or lactating)

Exclusion criteria

• Diabetic

• Smoker

• Have any food intolerances or allergies

• History of alcohol or drug misuse

• Diagnosed with any of the following:

  • High blood cholesterol
  • High blood pressure
  • Thyroid disorder
  • Heart problems, stroke or any vascular disease in the past 12 months
  • Inflammatory diseases such as rheumatoid arthritis
  • Bone related conditions, such as osteoporosis
  • Renal, gastrointestinal, respiratory, liver disease or cancer

• You are presently taking part in another clinical trial or research study

• You are an elite athlete (very high intensity training more than 3 times a week)

• You are currently on a specific diet or taking any dietary supplements and are unwilling to cease during the testing period

• You are intending to regularly use medication which affects gastrointestinal motility

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Single Blind

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24 participants in 2 patient groups

Low GI diet

Experimental group

Description:

This diet contained three meals, all with a low GI value. This was the Low Glycaemic Diet intervention.

Treatment:

Dietary Supplement: Low Glycaemic Diet

High GI diet

Experimental group

Description:

This diet contained three meals, all with a high GI value. This was the High Glycaemic Diet intervention.

Treatment:

Dietary Supplement: High Glycaemic Diet