The Effect of Green Tea and Vitamin C on Skin Health

U

University of Manchester

Status

Completed

Conditions

Skin Cancer

Treatments

Dietary Supplement: Green tea + vitamin C high dose
Dietary Supplement: Placebo capsule

Study type

Interventional

Funder types

Other

Identifiers

NCT01032031
BB/G005575/1
UKCRN 6911 (Registry Identifier)

Details and patient eligibility

About

There is little information on the effect of oral bioactive compounds on human skin clinically despite evidence of a beneficial effect from laboratory studies. The aim of this study is to examine the effect of oral bioactive compounds (green tea and vitamin C) on the health of human skin by measuring markers of skin health directly and skin nutrient uptake.

Full description

There is little information on the effect of oral catechin, a nutritionally relevant bioactive compound, on skin health in humans in vivo despite considerable evidence for protective effects in experimental studies. Vitamin C is essential for skin health and stabilises catechins in the gut lumen. Ultraviolet radiation (UVR) in sunlight is a key environmental stressor impacting on skin health. Effects include acute inflammation and longer term photodamage. OBJECTIVE: To examine the protective effect of catechin and vitamin C on UVR-induced inflammation. STUDY DESIGN (1) A double-blind randomised controlled nutritional study in 50 healthy volunteers. Volunteers will receive 3 months dietary supplement with high dose bioactive (n=25),or placebo (n=25). The aim is to quantify the influence of catechin/vitamin C on: UVR-induced inflammation Leukocyte infiltration Inflammatory mediators Markers of photoageing DNA damage Bioavailability will also be assessed (2) Bioavailability of catechin and vitamin C in skin and blood. Volunteers will receive active dietary supplement. Blood and urine samples will be taken over a period of 6 hours to determine blood bioavailability. Skin biopsies will also be taken to assess skin bioavailability. Volunteers will then receive 3 months of active dietary supplement followed by repeated sampling.

Enrollment

95 patients

Sex

All

Ages

18 to 65 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • Healthy adults
  • Sun-reactive skin type I / II

Exclusion criteria

  • History of skin cancer
  • History of a photosensitivity disorder
  • History of a generalised skin disorder
  • Sunbathing (including sunbeds) in the past 3 months
  • Pregnancy
  • Taking photoactive medicine
  • Drink tea > 2 cups/day
  • Taking nutritional supplements

Trial design

Primary purpose

Basic Science

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

Triple Blind

95 participants in 2 patient groups, including a placebo group

Green tea + vit C high dose
Active Comparator group
Treatment:
Dietary Supplement: Green tea + vitamin C high dose
Placebo
Placebo Comparator group
Treatment:
Dietary Supplement: Placebo capsule

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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