The Effect of Heart Rate on Cardiac Index in Patients With Left Ventricular Hypertrophy

University of Aarhus

Status: Terminated

Conditions: Diastolic Dysfunction; Heart Failure; Left Ventricular Hypertrophy; Heart Rate

Treatments: Device: Pacemaker

Study type: Interventional

Funder types: Other

Identifiers

NCT01241838

1717

Details and patient eligibility

About

The purpose of this study is to compare the effect of heart rate on cardiac index in patients with or without left ventricular hypertrophy. The study will be conducted in postoperative heart surgery patients with a pacemaker.

Enrollment: 11 patients

Sex: All

Ages: 30 to 90 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Scheduled heart surgery including thoracotomy
• Ejection fraction > 45%
• Duration of QRS complex < 120 milliseconds
• Sinus rhythm
• Planned perioperative temporary pacemaker

Group: Left ventricular hypertrophy:

Thickness of interventricular septum and posterior wall >11 mm.

Group: No left ventricular hypertrophy:

Thickness of interventricular septum and posterior wall <11 mm.

Exclusion criteria

• Active endocarditis
• Severe mitral insufficiency
• No patient consent

Trial design

11 participants in 2 patient groups, including a placebo group

Normal left ventricular size

Placebo Comparator group

Description:

Postoperative patient with normal left ventricular size

Treatment:

Device: Pacemaker

Left ventricular hypertrophy

Active Comparator group

Description:

Postoperative patient with left ventricular hypertrophy

Treatment:

Device: Pacemaker