The Effect of Heat Exposure on Physiological Markers

Lithuanian Sports University

Status: Completed

Conditions: Healthy Adult Male

Treatments: Other: Endogenous heating; Other: Exogenous heating

Study type: Interventional

Funder types: Other

Identifiers

NCT07064512

LithuananianSportsU-24

Details and patient eligibility

About

This study is the first to examine the effects of core temperature elevation on kynurenine pathway (KP) metabolites in healthy young males. It was hypothesized that rise in core temperature due to both pasive heating and exercise will initiate a stress response, affecting the concentration of KP metabolites. Additionally, it was expected that the exercise would produce more pronounced effects due to the increased cardiovascular, mechanical, and metabolic demands associated with it. Thus, the the main purpose of the present study was to investigate and to compare the effects of two distinct heat stress modalities on KP metabolites.

Enrollment: 11 patients

Sex: Male

Ages: 18 to 36 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• healthy adults;
• age between 18 - 36 years;
• physically active (exercising 2-3 times per week);
• non-smoking.

Exclusion criteria

• a body mass index (BMI) > 30 kg/m2;
• neurological, cardiovascular, metabolic, and/or inflammatory diseases, or conditions that could be worsened by exposure to interventions and that could affect experimental variables;
• involvement in temperature manipulation program for ≥ 3 months.

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Single Blind

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11 participants in 2 patient groups

Exogenous heating

Experimental group

Description:

Healthy young subjects participated received exogenous heating modality, where the participants sat immersed in a water bath at 43.5 ± 0.5°C and remained submerged until rectal temperature reached 39°C.

Treatment:

Other: Exogenous heating

Endogenous heating

Experimental group

Description:

Healthy young subjects participated received endogenous heating modality, the participant cycled at 60% of his VO2max until rectal temperature reached 39°C

Treatment:

Other: Endogenous heating