The Effect of HFNC on Exercise Capacity Compared to VM in COPD Patients Recovering From Acute Evacerbation

Guangzhou Medical University

Status: Unknown

Conditions: COPD

Treatments: Device: high flow nasal cannula; Device: Venturi mask

Study type: Interventional

Funder types: Other

Identifiers

NCT05097560

FAHGZ-20210811

Details and patient eligibility

About

Early PR is thought to be effective in COPD patients recovering from acute exacerbation, while the effect of HFNC during exercise training in these patients remains unclear. The study may provide evidence of early PR in COPD patients recovering from acute exacerbation.

Full description

We hypothesize that HFNC may increases exercise time in COPD patients recovering from acute exacerbation compare to VM. A randomized, cross-over clinical trial in which either HFNC or VM may be used as an adjunct in 10-MST in random order, respectively, will be performed to compare the endurance time. The physiological effect of HFNC and VM during exercise will also be measured to explore the mechanism.

Enrollment: 10 estimated patients

Sex: All

Ages: 40 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• hospitalized AECOPD patients
• be ambulatory by 48h after admission for AECOPD
• requires oxygen by screening exercise test

Exclusion criteria

• active coronary ischemia
• respiratory diseases other than COPD
• unstable vital signs
• unstable psychological status

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: None (Open label)

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10 participants in 2 patient groups

HFNC group

Experimental group

Description:

* Set FiO2 28% * Titrate the flow of HFNC at the highest tolerated value up to 60 L/min

Treatment:

Device: high flow nasal cannula

VM group

Active Comparator group

Description:

- Keep FiO2 constant with VM and HFNC during the two trial

Treatment:

Device: Venturi mask