The Effect of High and Low Roasted Coffee on Vascular Response

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University of Reading

Status

Completed

Conditions

Cardiovascular Disease

Treatments

Dietary Supplement: Low roast coffee
Dietary Supplement: High roast coffee
Dietary Supplement: Control (Caffeine dissolved in water)

Study type

Interventional

Funder types

Other

Identifiers

NCT01813981
COFF2011

Details and patient eligibility

About

Evidence suggests that a diet rich in plant phenolic compounds may induce beneficial vascular effects. Coffee is a good source of phenolic compounds called chlorogenic acids (CGA), however the level of CGA is reduced during the roasting process. The aim of this study is to investigate the effect of coffee roasting on vascular response. The investigators hypothesize that coffee roasted to a lesser extent will exert a favourable vascular response over more heavily roasted coffee due to the higher levels of CGA.

Enrollment

19 patients

Sex

Male

Ages

19 to 35 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • Male
  • A signed consent form
  • Age 19-35 years
  • Body mass index - 18.5-30 kg/m2
  • Normal blood pressure at screening (< 150/90)

Exclusion criteria

  • Blood pressure > 150/90 mmHg
  • Haemoglobin (anaemia marker) < 125 g/l
  • Gamma GT (liver enzymes) > 80 IU/l
  • Cholesterol > 6.5 mmol/l
  • Had suffered a myocardial infarction or stroke in the previous 12 months
  • Suffers from any reproductive disorder
  • Suffers from any blood-clotting disorder
  • Suffers from any metabolic disorders (e.g. diabetes or any other endocrine or liver diseases)
  • Any dietary restrictions or on a weight reducing diet
  • Drinking more than 21 units per week
  • On any lipid-modifying medication
  • On any blood pressure lowering medication
  • On any medication affecting blood clotting
  • Planning on altering consumption of vitamin supplements/fish oil capsules during the course of the study
  • Regular or vigorous exercise (3 times/week, 20 minutes each session)
  • Smoking
  • Vegetarians or vegans

Trial design

Primary purpose

Prevention

Allocation

Randomized

Interventional model

Crossover Assignment

Masking

Single Blind

19 participants in 3 patient groups, including a placebo group

High roast coffee
Placebo Comparator group
Description:
110mg caffeine with 108 mg chlorogenic acid at start of study
Treatment:
Dietary Supplement: Control (Caffeine dissolved in water)
Low roast coffee
Active Comparator group
Description:
110 mg caffeine with 235 mg chlorogenic acid at start of the study
Treatment:
Dietary Supplement: Low roast coffee
Control
Placebo Comparator group
Description:
110 mg caffeine at start of study
Treatment:
Dietary Supplement: High roast coffee

Trial contacts and locations

2

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Data sourced from clinicaltrials.gov

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