The Effect of High Dose Arginine Infusion on Hemodynamic and Peripheral Microcirculation

Medical Scientific Fund of the Mayor of Vienna

Status and phase: Completed; Phase 4

Conditions: Peripheral Arterial Occlusive Disease

Treatments: Dietary Supplement: Arginine; Dietary Supplement: Placebo

Study type: Interventional

Funder types: Other

Identifiers

NCT01682889

MUW_Arginin

Details and patient eligibility

About

The aim of this study was to investigate the effect of a 24- hrs L-arginine infusion on hemodynamic and on parameters of microcirculation in patients with peripheral arterial occlusive disease (PAOD).

Enrollment: 40 patients

Sex: All

Ages: 55 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• female or male patients receiving peripheral bypass surgery
• age between 55 and 75 years

Exclusion criteria

• metabolic acidosis

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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40 participants in 2 patient groups, including a placebo group

Placebo

Placebo Comparator group

Description:

NaCl 0.9% intravenously for 24 hours after induction of anaesthesia

Treatment:

Dietary Supplement: Placebo

Arginine

Active Comparator group

Description:

L-arginine-hydrochlorid (0.35 g/kg body weight) intravenously for 24 hours after induction of anaesthesia

Treatment:

Dietary Supplement: Arginine