The Effect of High Dose Vitamin C in Burn Patients

United States Army Institute of Surgical Research

Status

Withdrawn

Conditions

Burns

Treatments

Drug: Vitamin C

Drug: Intravenous Vitamin C

Study type

Interventional

Funder types

Other

Other U.S. Federal agency

Identifiers

NCT00350077

H-05-045

Details and patient eligibility

About

The purpose of this study is to see if intravenous Vitamin C will decrease the amount of IV fluids needed following burn injury in the first 48 hours.

Full description

Adequate fluid resuscitation in burn injured patients to allow adequate renal blood flow has been the hallmark of burn care in the last 50 years. The danger of exceeding the optimal intravenous fluid resuscitation has resulted in severe complications including abdominal compartment syndrome, loss of upper airway control, extremity compartment syndromes and pulmonary edema. Hig dose vitamin C infusion during the first 24 hours of burn resuscitation has been documented to decrease the overall amount of intravenous fluid needed to provide for adequate renal perfusion and hemodynamic stability in multiple animal model studies. High dose vitamin C is thought to decrease postburn microvascular protein and fluid leakage by reducing postburn lipid oxygenation caused by burn injury generated free radicals.

Sex

All

Ages

18 to 72 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

>/= 20% total body surface area full and partial thickness burns
Admitted to the USAISR burn center within 10 hours post injury

Exclusion criteria

Pregnant or breast feeding
Documented preadmission or admission renal failure
History of glucose-6-phosphate dehydrogenase deficiency, kidney stoves, gout or sickle cell
Electrical injury
Renal replacement of any kind<24 hours after admission