The Effect of High Dose Vitamin C on the Liver Function in Chronic Hepatitis Patients

Seoul National University

Status and phase

Completed

Phase 4

Conditions

Chronic Hepatitis

Chronic Alcoholic Hepatitis

Chronic Hepatitis C

Treatments

Drug: High dose vitamin C

Study type

Interventional

Funder types

Other

Identifiers

NCT01413360

VitC

Details and patient eligibility

About

The investigators will evaluate the efficacy of high dose vitamin C in chronic hepatitis patients whose serum liver enzymes are elevated more than upper limit.

Full description

The changes of laboratory findings including serum transaminase levels, serum albumin levels, Child-Pugh score, MELD score, and APRI score will be evaluated.

Enrollment

10 patients

Sex

All

Ages

18 to 80 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Chronic hepatitis C patients
- positive anti-HCV antibody more than 6 months
- serum alanine aminotransferase 40 - 80 IU/L for more than 6 months
- not indicated for antiviral therapy with interferon and ribavirin
Chronic alcoholic hepatitis
- significant alcohol drinking history and no other cause of chronic hepatitis
- serum alanine aminotransferase 40 - 80 IU/L for more than 6 months

Exclusion criteria

Chronic hepatitis B, autoimmune hepatitis, primary biliary cirrhosis, Wilson's disease, hemochromatosis, other chronic hepatitis except chronic hepatitis C or alcoholic hepatitis
decompensated liver cirrhosis
platelet < 50,000/uL or white blood cell < 1,500/uL
need and willing for antiviral therapy
significant renal dysfunction (GFR < 30 mL/min/kg) or history of renal stone
hepatotonic drug (i.e. silymarin, garlic oil, aronamin gold) usage within 2 weeks
pregnancy, lactating woman