The Effect of High Frequency Oscillation on Biological Markers of Lung Injury

Unity Health Toronto

Status: Completed

Conditions: Acute Respiratory Distress Syndrome

Study type: Observational

Funder types: Other

Identifiers

NCT00673517

OSCILLATE Biomarkers Substudy

Details and patient eligibility

About

Although mechanical ventilation is life saving, it is associated with a number of severe complications collectively referred to as ventilator induced lung injury (VILI). VILI contributes to the high morbidity and mortality associated with the acute respiratory distress syndrome (ARDS). Within the context of a randomized study evaluating the feasibility of conducting a study comparing high frequency oscillation to conventional lung protective ventilation in early severe ARDS, we are evaluating the effect of both ventilator strategies on biological markers of VILI.

Full description

Specific objectives:

To measure known biomarkers conventionally associated with VILI and biotrauma To measure potential novel biomarkers of VILI and biotrauma To identify the best time point for biomarker measurement To collect and store samples for differential expression and genomic analysis

Enrollment: 20 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

Informed consent previously obtained for enrollment in the OSCILLATE study:

1. Acute onset of respiratory failure
2. Endotracheal intubation or tracheostomy
3. Hypoxemia (P:F <200 mmHg)
4. Bilateral alveolar consolidation

Exclusion criteria

1. Refusal of consent to participate in this biomarkers substudy

Trial design

20 participants in 2 patient groups

1

Description:

Patients randomized to high frequency oscillation

2

Description:

Patients randomized to conventional lung protective ventilation