The Effect of Household Air Pollution on Lung Function Growth in Infants With Pneumonia in Sub-Saharan Africa (PLUS2)

Mass General Brigham

Status

Invitation-only

Conditions

Chronic Respiratory Disease

Pollution; Exposure

Pneumonia

Pediatric Respiratory Diseases

Lungs; Developmental Disorder

Lung Function Decreased

Treatments

Other: Clean Air Intervention

Study type

Interventional

Funder types

Other

Identifiers

NCT05724082

2019P000649

Details and patient eligibility

About

This study will evaluate the feasibility and acceptability of a household-based clean air intervention

Full description

A clean air intervention will be implemented in each household, including HEPA- based air filtration, solar lighting, and education. The air filtration system will be cycled monthly, with active filtration alternating with no filtration for one month on/one month off. To determine the effect of the clean air intervention within the household, PM2.5 concentration during each cycle and lung function will be measured among household members.

Enrollment

25 estimated patients

Sex

All

Ages

1 to 11 months old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Age < 12 months

• First episode of WHO-defined severe pneumonia22: cough or difficulty breathing with
Oxygen saturation < 90% or central cyanosis,
Severe respiratory distress, or
Signs of pneumonia with a general danger sign
Be willing to commit to entire 2 years of follow up visits.
(Controls) Matched to each case on age (+/-1 month), sex, and community

Exclusion criteria

Craniofacial, cardiac or other major malformation
Neuromuscular condition that affects respiration
Outside Smart Discharges Project catchment area
Prior hospitalizations or known episodes of respiratory illness or episodes of pneumonia before index admission,