the Effect of Hyaluronic Acid Intrauterine Wash on Endometrial Receptivity and Pregnancy Outcome

Al-Nahrain University

Status and phase: Enrolling; Phase 2

Conditions: Infertile Patients

Treatments: Drug: Hyaluronic Acid (HA); Drug: platlet rich plasma (PRP)

Study type: Interventional

Funder types: Other

Identifiers

NCT06937645

0701-PF-2023G12

Details and patient eligibility

About

Hyaluronic acid intrauterine wash is done for infertile females undergoing intracytoplasmic sperm injection on the day of oocyte retrieval. endometrial receptivity parameters, including the subendometrial vasculature indices were measured before and after the intervention for purpose of studying the effect of hyaluronic acid on improvement of the endometrial receptivity and subsequently the pregnancy outcome

Enrollment: 120 estimated patients

Sex: Female

Ages: 18 to 40 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Infertile females aged 18-40 years.
• Infertile females scheduled for GnRH antagonist protocol of fresh ICSI cycle.
• Females use dual stimulation (GnRH agonist plus Ovetrelle) for ovulation triggering.

Exclusion criteria

• Infertile females diagnosed as a poor responder.
• Infertile females diagnosed with uterine pathology.
• Infertile females who are scheduled for a frozen ICSI cycle.
• Infertile females diagnosed with endocrine diseases like thyroid disease, diabetes mellitus, and hyperprolactinemia.
• Infertile females diagnosed with thrombocytopenia.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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120 participants in 3 patient groups

the uterine cavity washed with hyaluronic acid preparation on the day of ooc

Experimental group

Description:

40 infertile patients had their uterine cavity with hyaluronic acid preparation on the day of oocytes retrieval in ICSI

Treatment:

Drug: Hyaluronic Acid (HA)

40 infertile females had their uterine cavity washed with PRP preparation

Experimental group

Description:

40 infertile females had their uterine cavity washed with PRP preparation on the day of oocytes retrieval in ICSI

Treatment:

Drug: platlet rich plasma (PRP)

40 infertile females with no intervention for their uterus

No Intervention group

Description:

40 infertile females with no intervention for their uterus on the day of oocytes retrieval in ICSI