The Effect of Hypercapnia on Physiological Parameters During Short-term Breathing (HYPERCO)

C

Czech Technical University in Prague

Status

Invitation-only

Conditions

Hypercapnia
Hypoxia
Cardiac Output, High

Treatments

Other: Hypoxic
Other: Hypoxic and Hypercapnic
Other: Hypercapnic

Study type

Interventional

Funder types

Other

Identifiers

NCT05441007
CTU HYPERCO

Details and patient eligibility

About

The aim of the project is to evaluate the effect of hypercapnia on physiological parameters in a healthy person during short-term hypoxia and hypercapnia.

Full description

Hypercapnia causes changes in physiological parameters at various levels throughout the body. The study aims to evaluate the effect of hypercapnia on physiological parameters in a healthy person during short-term hypoxia and hypercapnia. It is an intervention prospective study that will be conducted at the Faculty of Biomedical Engineering on healthy volunteers. All the volunteers undergo three different phases in random order. The individual phases differ in the breathed mixture of oxygen, nitrogen and carbon dioxide gases. Non-invasive measurements of physiological parameters, especially blood oxygen saturation, perfusion index and cardiac output, will be performed continuously during the experiment.

Enrollment

15 estimated patients

Sex

All

Ages

18 to 40 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Healthy volunteers

Exclusion criteria

  • pregnancy
  • severe cardiovascular conditions
  • severe asthma or other severe respiratory conditions
  • injury to the upper limbs or hands that could affect the peripheral perfusion
  • diabetes
  • hypotension or hypertension

Trial design

Primary purpose

Other

Allocation

Randomized

Interventional model

Crossover Assignment

Masking

Single Blind

15 participants in 3 patient groups

Hypoxic
Experimental group
Description:
Participants inhale ambient air, the hypoxic gas mixture, and ambient air.
Treatment:
Other: Hypoxic
Hypercapnic
Experimental group
Description:
Participants inhale ambient air, the hypercapnic gas mixture, and ambient air.
Treatment:
Other: Hypercapnic
Hypoxic and Hypercapnic
Experimental group
Description:
Participants inhale ambient air, the hypoxic and hypercapnic gas mixture, and ambient air.
Treatment:
Other: Hypoxic and Hypercapnic

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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