The Effect of Hypercapnia on Physiological Parameters During Short-term Breathing (HYPERCO)

Czech Technical University in Prague

Status: Invitation-only

Conditions: Hypercapnia; Hypoxia; Cardiac Output, High

Treatments: Other: Hypoxic; Other: Hypoxic and Hypercapnic; Other: Hypercapnic

Study type: Interventional

Funder types: Other

Identifiers

NCT05441007

CTU HYPERCO

Details and patient eligibility

About

The aim of the project is to evaluate the effect of hypercapnia on physiological parameters in a healthy person during short-term hypoxia and hypercapnia.

Full description

Hypercapnia causes changes in physiological parameters at various levels throughout the body. The study aims to evaluate the effect of hypercapnia on physiological parameters in a healthy person during short-term hypoxia and hypercapnia. It is an intervention prospective study that will be conducted at the Faculty of Biomedical Engineering on healthy volunteers. All the volunteers undergo three different phases in random order. The individual phases differ in the breathed mixture of oxygen, nitrogen and carbon dioxide gases. Non-invasive measurements of physiological parameters, especially blood oxygen saturation, perfusion index and cardiac output, will be performed continuously during the experiment.

Enrollment: 15 estimated patients

Sex: All

Ages: 18 to 40 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy volunteers

Exclusion criteria

• pregnancy
• severe cardiovascular conditions
• severe asthma or other severe respiratory conditions
• injury to the upper limbs or hands that could affect the peripheral perfusion
• diabetes
• hypotension or hypertension

Trial design

Primary purpose: Other

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Single Blind

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15 participants in 3 patient groups

Hypoxic

Experimental group

Description:

Participants inhale ambient air, the hypoxic gas mixture, and ambient air.

Treatment:

Other: Hypoxic

Hypercapnic

Experimental group

Description:

Participants inhale ambient air, the hypercapnic gas mixture, and ambient air.

Treatment:

Other: Hypercapnic

Hypoxic and Hypercapnic

Experimental group

Description:

Participants inhale ambient air, the hypoxic and hypercapnic gas mixture, and ambient air.

Treatment:

Other: Hypoxic and Hypercapnic