The Effect of Hyperoxia on Cardiac Output

Medical Centre Leeuwarden

Status: Completed

Conditions: Hyperoxia; Cardiac Output, Low

Study type: Observational

Funder types: Other

Identifiers

NCT03930979

nWMO270

Details and patient eligibility

About

Rational: Preoxygenation is a standard procedure before (deep) sedation in the ED. However, there is literature suggesting that too much oxygen can be harmful. One potential detrimental effect is a decrease in cardiac output due to coronary vasoconstriction. So far, it is unknown if this effect is rate dependent and if it also occurs after only a short period of hyperoxia, as patients experience during procedural sedation pre-oxygenation.

Objective: To investigate if hyperoxia has a negative effect on Cardiac index (CI) in patients undergoing procedural sedation in the ED.

Full description

Methods: In patients needing sedation for a painful condition, non-invasive measurements of CI, stroke volume and total peripheral resistance are performed using the Clearsight non-invasive cardiac output monitoring system.. Measurements will be taken at baseline, after 1,2 and 5 minutes of 15L O2/min, and then after another 2 and 5 minutes of flush rate oxygen and during the subsequent sedation.

Enrollment: 60 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients presenting in the ED of the Medical Center Leeuwarden (MCL) who have a painful condition for which procedural sedation is required.

Exclusion criteria

• • Cardiogenic shock (SBP<90 mmHg)
• Procedural sedation for cardioversion
• Pregnancy
• General contra-indications for the procedural sedation according to local sedation protocol of the MCL.
• Hypoxia (sat <90% or pO2 <8)) despite oxygen suppletion
• Age < 18 years
• Non-invasive ventilation (NIV) or intubation
• No informed consent
• Use of bleomycin
• COPD GOLD III of IV
• COPD GOLD I of II with hypercapnia (PCO2 > 6,4 kPa)
• Patients in whom no reliable signal for Clearsight measurement can be obtained

Trial design

60 participants in 1 patient group

Clearsight measurements

Description:

All patients presenting to the ED who have a painful condition for which procedural sedation is required will undergo Clearsight measurements