The Effect of Iloprost on Capillary Recruitment and Insulin Sensitivity in Type 2 Diabetes

Amsterdam UMC, location VUmc

Status

Completed

Conditions

Insulin Sensitivity/Resistance

Diabetes Mellitus, Type 2

Treatments

Drug: Iloprost infusion

Study type

Interventional

Funder types

Other

Identifiers

NCT03380325

Bootcamp1

Details and patient eligibility

About

This study examines the effects of iloprost - a stable prostacyclin analogue - on insulin-mediated muscle capillary recruitment and whole-body glucose uptake in a cross-over design.

Full description

In type 2 diabetes impaired insulin-mediated muscle perfusion is thought to contribute to reduced whole-body glucose uptake. This study aims to identify iloprost - a stable prostacyclin analogue - as a possible therapeutic option to increase whole-body glucose uptake via enhancement of muscle perfusion.

All participants will be subjected to two hyperinsulinemic-euglycemic clamps; one with and one without simultaneous iloprost infusion in a randomized cross-over design. Microvascular blood volume will be measured by means of contrast-enhanced ultrasonography.

Enrollment

15 patients

Sex

All

Ages

18 to 75 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Type 2 diabetes
Male or female (post-menopausal)
Age above 45 years and below 70 years
BMI >30 kg/m2
HbA1c < 80 mmol/mol or < 8,6% Subjects must use metformin
Stable medication use
Stable tension regulation (with or without medication)
Subjects should be able to give informed consent

Exclusion criteria

A history of cardiovascular event (Cerebrovascular event, myocardial infarction or pacemaker implantation)
Severe-very severe lung emphysema (GOLD stage III-IV)
Use of any antibiotics or proton pump inhibitor (PPI) in the past three months
Use of any other antidiabetic medication besides metformin (e.g. SU-derivates, insulin)
Use of a platelet inhibitor or cumarin derivate during
Subjects participated in a lifestyle programme in the past 6 months (diet or exercise)