The Effect of Iloprost on Oxygenation During One-lung Ventilation for Lung Surgery

Seoul St. Mary's Hospital

Status: Completed

Conditions: Lung Cancer

Treatments: Drug: Inhaled iloprost; Drug: Distilled water

Study type: Interventional

Funder types: Other

Identifiers

NCT03936140

KC14MISI0880

Details and patient eligibility

About

During one-lung ventilation in patients undergoing thoracic surgery, the persistent flow in the non-ventilated lung increases intrapulmonary shunt and decreases systemic arterial oxygenation. This prospective, randomized, double blind study was conducted to evaluate the effects of inhaled iloprost during one-lung ventilation on arterial oxygenation and shunt fraction during thoracic surgery.

Enrollment: 72 patients

Sex: All

Ages: 20 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• elective video-assisted thoracoscopic surgery (VATS) lobectomy
• 20 < age < 75
• American Society of Anesthesiologists (ASA) classification I~III

Exclusion criteria

• ASA classification IV
• New York Heart Association (NYHA) class III~IV
• Severe obstructive lung disease / restrictive lung disease
• Pulmonary hypertension
• End-stage organ disease (i.e. hepatic failure, renal failure)
• Arrhythmia
• Previous history of thoracic surgery

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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72 participants in 3 patient groups, including a placebo group

Iloprost 10

Experimental group

Description:

Iloprost 10μg of inhaled iloprost (Ventavis®) Study drug was inhaled to ventilated lung through a nebulized system in inspiratory limb after one-lung ventilation in the lateral decubitus position.

Treatment:

Drug: Inhaled iloprost

Iloprost 20

Experimental group

Description:

Iloprost 20μg of inhaled iloprost (Ventavis®) Study drug was inhaled to ventilated lung through a nebulized system in inspiratory limb after one-lung ventilation in the lateral decubitus position.

Treatment:

Drug: Inhaled iloprost

Distilled water

Placebo Comparator group

Description:

Distilled water Study drug was inhaled to ventilated lung through a nebulized system in inspiratory limb after one-lung ventilation in the lateral decubitus position.

Treatment:

Drug: Distilled water