The Effect of In-vitro Myoinositol Supplementation of Human Sperm on the Outcome of Cryopreservation

Sohag University

Status and phase: Completed; Phase 2; Phase 1

Conditions: Cryopreservation; Human; Myoinositol; Sperm

Treatments: Biological: Myoinositol

Study type: Interventional

Funder types: Other

Identifiers

NCT03153436

SPMYO001

Details and patient eligibility

About

The objective of this study is to evaluate the effect of in-vitro myoinositol supplementation of human sperm on the outcome of cryopreservation.

Full description

Sperm cryopreservation is considered the most valuable and used way to preserve male reproductive function. Unfortunately, osmotic effects of freezing and thawing during the cryopreservation process negatively affect sperm morphology and motility .

Myoinositol is the most biologically important form of inositol in nature. In male reproductive system, myoinositol appears to regulate sperm motility, capacitation and acrosomal reaction.

The objective of this study is to evaluate the effect of in-vitro myoinositol supplementation of human sperm on the outcome of cryopreservation.

Enrollment: 41 patients

Sex: Male

Ages: 20 to 60 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Infertile men with normal or abnormal semen analysis

Exclusion criteria

• Azoospermic samples

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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41 participants in 2 patient groups

Normal S.A group

Active Comparator group

Description:

Infertile men with normal semen analysis. each sample is divided into 2 identical aliquots: one aliquot (Myo aliquot) is supplied with myoinositol, The other aliquot is left as it is (control aliquot).

Treatment:

Biological: Myoinositol

Abnormal S.A group

Active Comparator group

Description:

Infertile men with abnormal semen analysis. each sample is divided into 2 identical aliquots: one aliquot (Myo aliquot) is supplied with myoinositol, The other aliquot is left as it is (control aliquot).

Treatment:

Biological: Myoinositol