"The Effect of Inhaled Nitroglycerin for COPD Patients (iNGCOPD)

Beni-Suef University

Status and phase: Enrolling; Phase 3; Phase 2

Conditions: COPD III/IV; COPD

Treatments: Drug: Inhaled nitroglycerin

Study type: Interventional

Funder types: Other

Identifiers

NCT06785337

REC-H-PhBSU-24020

Details and patient eligibility

About

this study aims to investigative the benefits of using nebulized nitroglycerin in improving respiratory functions in patients of late stage COPD

Full description

the inhaled nitroglycerin is expected to make vasodilatation of the pulmonary arteries and arterioles which are constricted in late stages of COBD leading to ventilation/perfusion mismatching and further aggravating COPD. it will also help in delivering better antibiotic concentrations to the alveoli which help in better control of infection.

Enrollment: 40 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Adult patient's ≥ 18 years old COPD exacerbation with respiratory failure and Echo evidenced presence of pulmonary hypertension (defined as mean pulmonary artery pressure > 20 mmHg)

Exclusion criteria

• Profound left ventricular failure, as the decrease in pulmonary vascular resistance results in an increase in left ventricular preload. This may worsen cardiogenic pulmonary edema.
• Pregnant female patients
• Patient with hypersensitivity to nitroglycerin

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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40 participants in 2 patient groups

Control arm

No Intervention group

Description:

will receive standard COPD exacerbation treatment protocol including antibiotics, corticosteroids and bronchodilator only

Intervention group

Experimental group

Description:

will receive inhaled nitroglycerin in addition to standard COPD exacerbation treatment protocol

Treatment:

Drug: Inhaled nitroglycerin