The Effect of Intensive Insulin Therapy

University Medical Centre Ljubljana

Status: Completed

Conditions: the Maintenance of Normoglycemia; Treatment Period in the Intensive Care Unit; the Incidence of Ventilator Associated Pneumonia (VAP)

Treatments: Procedure: glucontrol (insulin therapy)

Study type: Interventional

Funder types: Other

Identifiers

NCT00447239

gluco study

Details and patient eligibility

About

Aim. To determine whether the maintenance of normoglycemia decreases the incidence of ventilator associated pneumonia (VAP), reduces its treatment period and the length of stay in the intensive care unit.

Methods. Prospective, randomized, controlled trial. We enrolled 117 mechanically ventilated trauma (71) and abdominal (46) surgical patients, older than 18, of both sex. In 57 patients (strict glucose control group) we aimed to maintain the blood glucose level between 4.4 and 6. 1 mmol/L, while in 60 patients (standard glucose control group) it was maintained between 7.8 and 10.0 mmol/L, with the use of continues insulin infusion. Insulin dose adjustments were based on measurements of glucose in capillary blood sample.

Key words: surgical patients; mechanical ventilation; pneumonia; blood glucose; insulin infusion; hospital stay

Full description

see brief summary

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• surgical patients
• mechanical ventilated
• both sex
• older than 18

Exclusion criteria

• non-surgical patients
• non mechanical ventilated
• younger than 18
• pregnant women

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind