The Effect of Intra-articular Pulsed Radiofrequency in Osteoarthritis

Tri-Service General Hospital

Status: Withdrawn

Conditions: Osteoarthritis

Treatments: Device: pulsed radiofrequency (Neurotherm NT1000, Neurotherm Inc., USA)

Study type: Interventional

Funder types: Other

Identifiers

NCT02436434

TriServiceGH

Details and patient eligibility

About

Pulsed radiofrequency (PRF) is designed to alleviate pain by delivering an electrical field and heat bursts at a temperature less than 42°C to neural tissue. In contrast with conventional radiofrequency, PRF is controlled below 42°C without damage to nerves and many studies have shown its benefits in pain relief for certain kinds of chronic pain conditions. For lessening pain of certain joint arthropathy, the direct nerve block by application of PRF is difficult and complicated because the supplying nerve of joint is complex or small. Hence, some authors perform intra-articular PRF on the chronic painful joint for example, knee osteoarthritis, atlantoaxial joint, cervical facet joint sacroiliac joint, scapholunate and shoulder joint and the excellent long-term effects are reported.

The purpose of this study is to investigate the effect of intra-articular PRF in osteoarthritis.

Full description

Pulsed radiofrequency (PRF) is designed to alleviate pain by delivering an electrical field and heat bursts at a temperature less than 42°C to neural tissue. In contrast with conventional radiofrequency, PRF is controlled below 42°C without damage to nerves and many studies have shown its benefits in pain relief for certain kinds of chronic pain conditions. For lessening pain of certain joint arthropathy, the direct nerve block by application of PRF is difficult and complicated because the supplying nerve of joint is complex or small. Hence, some authors perform intra-articular PRF on the chronic painful joint for example, knee osteoarthritis, atlantoaxial joint, cervical facet joint sacroiliac joint, scapholunate and shoulder joint and the excellent long-term effects are reported.

However, the definite effect of intra-articular PRF for osteoarthritis from current published studies are insufficiently proved because of small patient numbers and lack of placebo-controlled design. The purpose of this study is to investigate the effect of intra-articular PRF in osteoarthritis.

Sex: All

Ages: 30 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age between 30-75 year-old
• Clear consciousness
• No receive steroid injection, hyaluronic acid, platelet rich plasma in past 6 months
• The pain (VAS) more than 4
• Symptom duration at least 6 months

Exclusion criteria

• Cancer
• Joint contracture
• Coagulopathy
• Pregnancy
• Status of Pacemaker
• Inflammation status
• Operative history of treated joint

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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0 participants in 2 patient groups

pulsed radiofrequency

Active Comparator group

Description:

Intra-articular pulsed radiofrequency (Neurotherm NT1000, Neurotherm Inc., USA) in treated joint

Treatment:

Device: pulsed radiofrequency (Neurotherm NT1000, Neurotherm Inc., USA)

Sham pulsed radiofrequency

Sham Comparator group

Description:

Sham intra-articular pulsed radiofrequency (Neurotherm NT1000, Neurotherm Inc., USA) in controlled joint

Treatment:

Device: pulsed radiofrequency (Neurotherm NT1000, Neurotherm Inc., USA)