The Effect of Intracameral Cefuroxime on Post-op Fibrin in Pediatric Cataract Surgery

Presbyterian Church East Africa Kikuyu Hospital

Status: Completed

Conditions: Cataract; Endophthalmitis

Treatments: Drug: Saline placebo; Drug: cefuroxime

Study type: Interventional

Funder types: Other

Identifiers

NCT00730938

Kikuyu01

Details and patient eligibility

About

The study investigates whether placing an antibiotic inside the eye at the end of cataract surgery in children will reduce the amount of fibrin formation (fibrin formation can block the pupil and reduce vision). We hypothesize that the fibrin is caused by a low-level infection and could be prevented by the antibiotic.

Full description

The study investigates whether using an antibiotic (cefuroxime) in the anterior chamber of the eye at the end of surgery for cataract in children will reduce the amount of fibrin formation.

Enrollment: 45 patients

Sex: All

Ages: 6 months to 15 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• bilateral congenital or developmental pediatric cataract

Exclusion criteria

• traumatic cataract

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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45 participants in 2 patient groups, including a placebo group

1

Active Comparator group

Treatment:

Drug: cefuroxime

2

Placebo Comparator group

Description:

Saline placebo

Treatment:

Drug: Saline placebo