The Effect of Intranasally Administered Nitroglycerin on Hemodynamic Response to Laryngoscopy and Intubation Among Patients Undergoing Coronary Artery Bypass Grafting (CABG) Surgery

Muhammad Aamir Latif

Status: Completed

Conditions: Coronary Artery Bypass Grafting

Treatments: Drug: Nitroglycerin (NTG)

Study type: Interventional

Funder types: Other

Identifiers

NCT06637956

PIC_Lahore

Details and patient eligibility

About

Numerous preventive medications have been used to lessen the cardiovascular response to laryngoscopy and intubation. Though some advantages have been noted, most of these treatments have not been found to be completely satisfying. However, nitroglycerin is the most widely utilized medicine due to its fast effect, short half-life, and absence of sedative qualities.

Full description

The circulatory system under compromise is less resilient to the effects of general anaesthesia. Inducing anaesthesia is a crucial step for cardiac patients because their impaired circulatory systems are less tolerant to depression. During coronary artery bypass grafting surgery, the primary objective of general anesthesia is to reduce sympathetic response to uncomfortable stimuli, including laryngoscopy, intubation, skin incision, sternal splitting, and spreading. A rise in blood pressure is one of the hemodynamic reactions that is typically associated with tracheal intubation and laryngoscopy. The impact of intra nasally delivered nitroglycerin on blood pressure response to laryngoscopy and intubation in patients having non-cardiac surgery is currently contentious; however, this study focus on coronary artery bypass grafting surgery patients.

Enrollment: 58 patients

Sex: All

Ages: 35 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Both genders
• Patients undergoing coronary artery bypass grafting surgery.
• Patients aged 35-60 years.
• Ejection Fraction between 50-60%.
• American Society of Anesthesiologists Classification 3-4.

Exclusion criteria

• Known hypersensitivity to nitroglycerin.
• Anticipated difficult airway.
• Emergency surgery.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

---

58 participants in 2 patient groups

NTG

Experimental group

Description:

Received a mg nitroglycerin intranasally two minutes prior to laryngoscopy and intubation

Treatment:

Drug: Nitroglycerin (NTG)

Control

No Intervention group

Description:

Control group did not receive nitroglycerine prior to laryngoscopy and intubation