The Effect of Intravenous Lidocaine and Intraperitoneal Lidocaine Irrigation on Pain After Laparoscopic Cholecystectomy

Chung-Ang University Hosptial, Chung-Ang University College of Medicine

Status and phase: Unknown; Phase 4

Conditions: Postoperative Pain

Treatments: Drug: Intravenous lidocaine injection; Drug: Intravenous normal saline injection; Drug: Intraperitoneal lidocaine irrigation group

Study type: Interventional

Funder types: Other

Identifiers

NCT01608373

ChungAngUH4

Details and patient eligibility

About

This prospective randomized study aims to comparison the effectiveness of intravenous lidocaine injection and intraperitoneam lidocaine irrigation on the relief of pain in patients undergoing laparoscopic cholecystectomy.

A total of 83 patients will be randomized into one of three groups (group C or group I or group P) based on Excel number generation.

Patients in group C will receive normal saline intravenous injection, and patients in group I will receive an intravenous bolus injection of 1.5 mg/kg lidocaine followed by a continuous lidocaine infusion of 2 mg/kg/hr.

Patients in group P will receive intraperitoneal lidocaine irrigation with 3.5 mg/kg lidocaine and normal saline 100cc.

Visual analogue scale pain scores, fentanyl consumption and the frequency at which patients pushed the button (FPB) of a patient-controlled analgesia system will be recorded at 2, 4, 8, 12, 24, 48 hours postoperatively.

Enrollment: 83 estimated patients

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Laparoscopic cholecystectomy

Exclusion criteria

• mental change
• allergy to local anesthetics

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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83 participants in 3 patient groups, including a placebo group

Intravenous lidocaine injection group

Active Comparator group

Description:

Patients in Group I (intravenous lidocaine injection group) received an intravenous bolus injection of 1.5 mg/kg lidocaine followed by a continuous lidocaine infusion of 2 mg/kg/hr.

Treatment:

Drug: Intravenous lidocaine injection

Intraperitoneal lidocaine irrigation group

Active Comparator group

Description:

Patients in Group P(intraperitoneal lidocaine irrigation group) receive a peritoneal lidocaine irrigation with 3.5mg/kg lidocaine and normal saline 100cc.

Treatment:

Drug: Intraperitoneal lidocaine irrigation group

Intravenous normal saline group

Placebo Comparator group

Description:

The patients in Group C (placebo control group) received normal saline intravenous injection

Treatment:

Drug: Intravenous normal saline injection