The Effect of Intravenous Lidocaine on Pain After Lumbar Spinal Fusion

Chung-Ang University Hosptial, Chung-Ang University College of Medicine

Status and phase: Completed; Phase 4

Conditions: Postoperative Pain

Treatments: Drug: Intravenous lidocaine injection; Drug: Intravenous normal saline injection

Study type: Interventional

Funder types: Other

Identifiers

NCT01319682

ChungAngUH2

Details and patient eligibility

About

This prospective randomized study aims to evaluate the effectiveness of intravenous lidocaine injection on the relief of pain in patients undergoing 1-level posterior lumbar fusion.

A total of 54 patients will be randomized into one of two groups (group C or group I) based on Excel number generation.

Patients in group C will receive received normal saline intravenous injection, and patients in group I will receive an intravenous bolus injection of 1.5 mg/kg lidocaine followed by a continuous lidocaine infusion of 2 mg/kg/hr.

Visual analogue scale pain scores, fentanyl consumption and the frequency at which patients pushed the button (FPB) of a patient-controlled analgesia system will be recorded at 4, 12, 24, 48 hours postoperatively.

Enrollment: 54 patients

Sex: All

Ages: 18 to 85 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• 1-level posterior lumbar fusion

Exclusion criteria

• mental change
• allergy to local anesthetics
• chronic analgesics user

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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54 participants in 2 patient groups, including a placebo group

Intravenous lidocaine injection group

Active Comparator group

Description:

Patients in Group I (intravenous lidocaine injection group) received an intravenous bolus injection of 1.5 mg/kg lidocaine followed by a continuous lidocaine infusion of 2 mg/kg/hr.

Treatment:

Drug: Intravenous lidocaine injection

Placebo control group

Placebo Comparator group

Description:

Patients in Group C (placebo control group) received normal saline intravenous injection

Treatment:

Drug: Intravenous normal saline injection