The Effect of Intravenous Lidocaine on Pain After Thyroidectomy

Chung-Ang University Hosptial, Chung-Ang University College of Medicine

Status and phase: Unknown; Phase 4

Conditions: Postoperative Pain

Treatments: Drug: Intravenous lidocaine injection; Drug: Intravenous normal saline injection

Study type: Interventional

Funder types: Other

Identifiers

NCT01608360

ChungAngUH3

Details and patient eligibility

About

This prospective randomized study aims to evaluate the effectiveness of intravenous lidocaine injection on the relief of pain in patients undergoing thyroidectomy.

A total 56 patients will be randomized into one of two groups(group C or group I) based on Excel number generation.

Patients in group C will receive normal saline intravenous injection, and patients in group I will receive an intravenous bolus injection of 1.5mg/kg lidocaine followed by a continuous lidocaine infusion of 2mg/kg/hr.

Visual analogue scale pain scores, fentanyl consumption, the frequency at which patients pushed the button(FPB) of a patient-controlled analgesia system, and presence or absence of nausea and vomiting will be recorded at 2,4,8,12,24,48 hours postoperatively.

Enrollment: 56 estimated patients

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Total thyroidectomy

Exclusion criteria

• mental change
• allergy to local anesthetics

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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56 participants in 2 patient groups, including a placebo group

Intravenous lidocaine injection group

Active Comparator group

Description:

Patients in Group I (intravenous lidocaine injection group) received an intravenous bolus injection of 1.5 mg/kg lidocaine followed by a continuous lidocaine infusion of 2 mg/kg/hr.

Treatment:

Drug: Intravenous lidocaine injection

Placebo control group

Placebo Comparator group

Description:

Patients in Group C (placebo control group) received normal saline intravenous injection

Treatment:

Drug: Intravenous normal saline injection