The Effect of Intravenous Lidocaine on Postoperative Cognitive Function in Elderly Patients

General Hospital of Ningxia Medical University

Status: Not yet enrolling

Conditions: Organ Protection

Treatments: Drug: Lidocaine; Other: Normal saline (NS)

Study type: Interventional

Funder types: Other

Identifiers

NCT05502705

Yujingfang202201

Details and patient eligibility

About

The purpose of this study is to investigate the efficacy of intravenous lidocaine on BDNF, NGF, miRNA-206 and miRNA-98 in serum in elderly patients undergoing abdominal surgery under general anesthesia.

Full description

Postoperative cognitive dysfunction (POCD) is a major complication following surgeries and anesthesia, especially in elderly individuals. Lidocaine, an inexpensive, widely available, and relatively safe compound, is a local anesthetic that readily crosses the blood-brain barrier. Intravenous lidocaine can reduce the incidence of POCD. However, the mechanism is still unclear.

Brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF), which are regulated by miRNA-206 and miRNA-98 respectively, play a key role in learning, memory, and cognition. Previous studies have shown that the levels of BDNF and NGF can be improved by lidocaine.

The objective of this study is to investigate the efficacy of intravenous lidocaine on the incidence of early POCD, and the levels of BDNF, NGF, miRNA-206 and miRNA-98 in elderly patients undergoing abdominal surgery under general anesthesia.

Enrollment: 50 estimated patients

Sex: All

Ages: 65 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients were scheduled by following abdominal surgery under general anesthesia
• Aged 65 - 80 years
• ASA physical status Ⅱ-Ⅲ

Exclusion criteria

• Severe heart, pulmonary, hepatic and renal insufficiency
• History of neurological diseases (including Alzheimer's disease and stroke history)
• Psychological disorder, and drug or alcohol abuse
• History of anesthesia and surgery
• psychiatric illness
• Unwillingness to comply with the protocol or procedures
• Allergic to lidocaine
• Mini-Mental State Examination (MMSE) score<23 before surgery

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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50 participants in 2 patient groups, including a placebo group

Lidocaine

Experimental group

Description:

Intravenous bolus of 1.5 mg/kg of lidocaine followed by a continuous infusion of 3.0 mg/kg for the first hour, 1.5 mg/kg for the second hour, 0.7 mg/kg until the end of the surgery.

Treatment:

Drug: Lidocaine

Normal saline

Placebo Comparator group

Description:

Normal saline administered as a bolus and an infusion with identical volume and rate changes as the treatment group.

Treatment:

Other: Normal saline (NS)