The Effect of Ischaemic-reperfusion on the Endogenous Fibrinolysis in Man

University of Edinburgh

Status: Completed

Conditions: Ischaemic Heart Diseases

Treatments: Procedure: Forearm vascular study

Study type: Interventional

Funder types: Other

Identifiers

NCT00789451

CMP 1

Details and patient eligibility

About

Heart attacks are usually caused by a blood clot blocking an artery supplying blood to the heart. Current treatments are designed at relieving this blockage as quickly as possible to minimise damage to the heart muscle. However in restoring the supply of blood local damage known as "ischaemia-reperfusion injury" may occur. The aim of this study is to assess how clot forming and clot dissolving pathways are affected during this process, and examine the role of a natural inflammatory hormone, bradykinin. This will help us to understand the mechanism by which ischaemia-reperfusion injury may occur and to devise new treatments for heart attacks.

Enrollment: 12 estimated patients

Sex: Male

Ages: 18 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy males between 18-65 years of ages, non-smokers.

Exclusion criteria

• Any concurrent illness or chronic medical condition. Concurrent use of vasoactive medication. Smoking history.

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Double Blind

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12 participants in 2 patient groups

1

Sham Comparator group

Description:

no ischaemia - only sham. Blood pressure cuff inflation up till 10 mmHg on the upper arm for 20 mins.

Treatment:

Procedure: Forearm vascular study

2

Active Comparator group

Description:

Ischaemia 20 minutes. Blood pressure cuff will be inflated around the upper arm for 20 minutes to induce ischaemia.

Treatment:

Procedure: Forearm vascular study