The Effect of Ischemic Pre-Conditioning on the Rate of Recovery Following Exercise-Induced Muscle Damage

St Mary's University College

Status: Completed

Conditions: Exercise-induced Muscle Damage

Treatments: Other: Ischemic Preconditioning

Study type: Interventional

Funder types: Other

Identifiers

NCT01907841

IPCEIMD001

Details and patient eligibility

About

Strenuous exercise or exercise involving eccentric muscle contractions can lead to muscle damage and changes in muscle function; this is known as exercise-induced muscle damage (EIMD). It is known that brief, repeated periods of ischemia followed by reperfusion, known as Ischemic Preconditioning (IPC) cause a delay in cell injury in cardiac muscle as well as in various other organs.

Therefore the purpose of this study is to:

1. Quantify the use of IPC in recovery following EIMD.
2. Identify any effect of IPC during recovery on muscle function

Enrollment: 24 estimated patients

Sex: Male

Ages: 18 to 45 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Physically Active Males

Exclusion criteria

• Muscular skeletal disorders

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

---

24 participants in 2 patient groups, including a placebo group

Ischemic Preconditioning

Experimental group

Description:

IPC (4 x 5 minute cycles @ 220 mmHg) with 5 min reperfusion between trials.

Treatment:

Other: Ischemic Preconditioning

Ischemic Preconditioning Placebo

Placebo Comparator group

Description:

Placebo (4 x 5 minute cycles @ 20mmHg) with 5 minutes between each cycle

Treatment:

Other: Ischemic Preconditioning