The Effect of Isokinetic Strengthening Training

Taichung Veterans General Hospital

Status: Enrolling

Conditions: Arthroplasty, Replacement, Hip; Arthroplasty, Replacement, Knee; Stroke; Resistance Training

Treatments: Device: Isokinetic strengthening exercise; Device: Isotonic strengthening exercise; Behavioral: isometric strengthening exercise

Study type: Interventional

Funder types: Other

Identifiers

NCT02938416

CF12251

Details and patient eligibility

About

Our participants will include 40 patients within one month of stroke, 43 patients who received total hip replacement or total knee replacement two to four weeks before. The participants will be randomly assigned to isokinetic, isotonic or isometric training groups. Outcome measures including isometric peak torque of hip/knee at 90 degree of flexion, peak torque of hip/knee at angular velocity of 60 degree/s and 120 degree/s, Short Form 36 (SF-36), the Timed Up and Go test, the Oxford Hip/knee Score, the plasma concentration of hsCRP, and the level of substance P in saliva will be collected at the beginning and 4 weeks after the training program. Statistical significant differences will be determined between the improvement of outcome measures of the isokinetic and the isotonic training groups.

Full description

Our participants will include 40 patients within one month of stroke, 43 patients who received total hip replacement or total knee replacement two to four weeks before. The participants will be randomly assigned to isokinetic, isotonic or isometric training groups. Outcome measures including isometric peak torque of hip/knee at 90 degree of flexion, peak torque of hip/knee at angular velocity of 60 degree/s and 120 degree/s, Short Form 36 (SF-36), the Timed Up and Go test, the Oxford Hip/knee Score, the plasma concentration of hsCRP, and the level of substance P in saliva will be collected at the beginning and 4 weeks after the training program. Statistical significant differences will be determined between the

Enrollment: 126 estimated patients

Sex: All

Ages: 40 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• within one month of acute stroke
• receive total hip/knee replacement within two to four weeks before

Exclusion criteria

• cannot perform from sitting to standing
• Body Mass Index > 30
• Lower limbs fracture history
• Diabetic polyneuropathy
• Cardiopulmonary diseases that impede exercise prescription
• Impaired cognitive function
• Infectious disease during the study period that may cause cytokine changes

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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126 participants in 3 patient groups, including a placebo group

Isokinetic training

Experimental group

Description:

Ten times, three sets of isokinetic strengthening exercise using 30 degree/sec and 120 degree/sec

Treatment:

Device: Isokinetic strengthening exercise

Isotonic training

Active Comparator group

Description:

Ten times, three sets of isotonic strengthening exercise using consistent resistance of 60% of 1-repetition maximum of hip or knee

Treatment:

Device: Isotonic strengthening exercise

isometric training

Placebo Comparator group

Description:

home exercise education on isometric quadriceps strengthening on the day of out-patient appointment

Treatment:

Behavioral: isometric strengthening exercise