The Effect of Juice Types on the Responses to Air Pollution

Rutgers The State University of New Jersey

Status: Completed

Conditions: Air Pollution

Treatments: Dietary Supplement: Orange juice; Dietary Supplement: Beet juice

Study type: Interventional

Funder types: Other

Identifiers

NCT02027415

Pro2013003273

Details and patient eligibility

About

The study hypothesis is that drinking different juices will affect the body's responses to air pollution. Subjects will be exposed to air pollution during a 2-hour car ride on the NJ (New Jersey) Turnpike. Each subject will be asked to do this twice. Before one car ride, the subject will be asked to drink orange juice. Before the other car ride, the subject will be asked to drink beet juice. Samples of blood and exhaled breath will be collected before, immediately after, and 24 hours after each car ride. Levels of nitrites/nitrates will be measured in the blood and breath.

Full description

Subjects will participate in two exposure sessions. The air pollution exposure consists of a 2-hour car ride along the NJ Turnpike. Samples will be collected at 3 time points for each exposure session: pre-exposure, immediately post-exposure, and 24 hours post-exposure. Blood samples will be collected immediately before and after a 5-minute occlusion at each time point. The subject will also be asked to provide samples of exhaled breath and complete symptom and stress questionnaires at each time point.

Blood samples will be analyzed for serum nitrite. Exhaled breath samples will be analyzed for nitrates and nitrites.

Enrollment: 24 patients

Sex: All

Ages: 18 to 40 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy
• Must live within 20 miles of Piscataway, NJ

Exclusion criteria

• • Are a current smoker

  • Are pregnant or breastfeeding
  • Are HIV-positive
  • Have an active medical condition such as high blood pressure, asthma, diabetes or other serious disease
  • Have a heart condition such as atrial flutter, atrial fibrillation or a pacemaker
  • Are unable to ride comfortably in a car for 2 hours
  • Travel to the EOHSI (Environmental and Occupational Health Sciences Institute) Clinic Center on major highways for more than 3 miles (the Garden State Parkway, the New Jersey Turnpike, Routes 287, 1, 18, or 9).

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: None (Open label)

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24 participants in 2 patient groups

Beet Orange

Experimental group

Description:

Beet juice will be given prior to the first car ride and orange juice will be given prior to the second car ride.

Treatment:

Dietary Supplement: Orange juice

Dietary Supplement: Beet juice

Orange Beet

Experimental group

Description:

Orange juice will be given before the first car ride and beet juice will be given before the second car ride.

Treatment:

Dietary Supplement: Orange juice

Dietary Supplement: Beet juice