The Effect of Ketone Esters on Forearm Glucose Metabolism (KAV)

University of Exeter

Status: Enrolling

Conditions: Healthy

Treatments: Dietary Supplement: Ketone supplement; Dietary Supplement: Placebo supplement

Study type: Interventional

Funder types: Other

Identifiers

NCT06685913

5390017

Details and patient eligibility

About

Ketones are naturally produced by our body and can affect our blood sugar levels. Ketones could be important tool for treating disease or recovering from exercise. The purpose of this research is to determine if a ketone drink can increase sugar uptake in our muscles. This research will provide new knowledge about the regulation of blood sugar.

Full description

Impaired skeletal muscle glucose uptake following a meal ("insulin resistance"), is a primary risk factor for developing type 2 diabetes. We and others have consistently shown that ingesting exogenous ketones can reduce blood glucose concentration. Mechanistically, this must arise through reduced glucose release (i.e. from liver), and/or increased uptake (i.e. into skeletal muscle). Our current MRC-funded work is focussing on ketone-liver interactions in patients with type 2 diabetes. Here we aim to investigate how KE influence skeletal muscle glucose metabolism.

Enrollment: 14 estimated patients

Sex: All

Ages: 18 to 40 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Age 18-40

Exclusion criteria

• Any diagnosed metabolic health condition
• Pregnant
• Smoker
• Diagnosed Cardiovascular disease
• Use of medications deemed by research team to affect study outcomes
• Recent history of musculoskeletal injury
• Aged >40 or <18
• Allergy to ingredients in the supplement, including ketones, lactose or milk protein

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Quadruple Blind

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14 participants in 2 patient groups, including a placebo group

Ketone supplementation

Experimental group

Description:

100 mL flavoured drink containing 0.3 g/kg ketone monoester ((R)-3-hydroxybutyl (R)-3-hydroxybutyrate; ΔG®, University of Oxford; https://www.deltagketones.com)

Treatment:

Dietary Supplement: Ketone supplement

Placebo

Placebo Comparator group

Description:

Placebo with bitter agent to flavour match

Treatment:

Dietary Supplement: Placebo supplement