The Effect of Kiwi on Blood Pressure, Endothelial Function, Antioxidant Capacity and Gene Expression
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About
The purpose of this study is to determine whether the intake of kiwi fruits will reduce systolic and diastolic blood pressure compared to intake of apples. The investigators hypothesize that the increased intake lutein or other components in the kiwi fruit will enhance nitric oxide bioavailability and lead to vascular relaxation.
Full description
An interesting finding in the Oslo Antioxidant Study was that intake of 3 kiwi fruits reduced blood pressure in a clinical significant manner compared to controls. The mechanism for the blood pressure reducing effect of kiwi or the responsible components are not elucidated. However, plasma lutein levels and antioxidant capacity measured by the ferric reducing antioxidant power was increased in the kiwi group. Moreover, gene expression was also altered by the increased intake of kiwi.
Enrollment
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Inclusion criteria
- Systolic blood pressure 130-159 mmHg
- Diastolic blood pressure 85-99 mmHg
- Body mass index <35 kg/m2
Exclusion criteria
- Systolic blood pressure >160 mmHg or <129 mmHg
- Diastolic blood pressure >100 mmHg or <84 mmHg
- Current use or need for blood pressure lowering medication
- Symptomatic cardiovascular disease, diabetes, renal dysfunction, psychiatric disorder, pregnancy or lactation, history of obesity surgery.
Trial design
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Allocation
Interventional model
Masking
118 participants in 2 patient groups, including a placebo group
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Data sourced from clinicaltrials.gov
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