ClinicalTrials.Veeva

Menu

The Effect of L-Citrulline Malate on Ankle Brachial Index Among Patients With Coronary Heart Disease

M

Masih Daneshvari Hospital

Status and phase

Unknown
Early Phase 1

Conditions

Coronary Heart Disease

Treatments

Drug: L-Citrulline malate

Study type

Interventional

Funder types

Other

Identifiers

NCT01917123
f-91-128

Details and patient eligibility

About

In this randomized clinical trial before and after study we will assess the effect of L-citrulline malate on brachial index in patients with coronary heart disease based on their smoking history. Twenty patients with coronary heart disease with no history of diabetes or other chronic diseases and with no history of myocardial infarction in the last 6 months will participate in our trial.A written well-versed permission was attained from all patients. We will measure the brachial index tow times once before giving L-Citrulline malate and the other time after 2 weeks giving it.Patients receiving L-Citrulline malate as a 1 gram dry powder agent twice a day, that should in use with 250 mg dilute water .The patients will followed after 2 weeks by measuring brachial index which is our primary outcome measurement in this trial.We assumed that the brachial index in both smoker and non-smoker group of patients with coronary heart disease would change to normal or close to normal after giving 1 gram L-citrulline malate twice a day for 2 weeks.

Enrollment

20 estimated patients

Sex

All

Ages

16 to 70 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

1- patients with coronary heart disease without history of diabetes or any chronic disease 2- no myocardial infarction in last 6 months 3-ejection fraction more than 50% 4- please to recruit in the trial 5-no uncontrolled blood pressure 6- with stable condition when come to the clinic

Exclusion criteria

1- those who refuse to being in the trial 2- those which their total condition become worse 3- CCU admission as a result of being unstable 4- patients with chronic heart failure(CHF)

Trial design

Primary purpose

Treatment

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

None (Open label)

20 participants in 2 patient groups, including a placebo group

Stimol, Brachial Index, Powder agent
Active Comparator group
Description:
L-Citrulline malate,1gr,twice a day,2weeks
Treatment:
Drug: L-Citrulline malate
Placebo, Brachial Index, Powder agent
Placebo Comparator group
Description:
Placebo,1gr,twice a day,2weeks

Trial contacts and locations

1

Loading...

Central trial contact

Babak Sharif-Kashani, cardiologist; Paritash Tahmaseb-pour, M.D

Data sourced from clinicaltrials.gov

Clinical trials

Find clinical trialsTrials by location
© Copyright 2024 Veeva Systems