The Effect of Lactisole on the Responses to Glucose Solution

Northern Care Alliance NHS Foundation Trust

Status: Unknown

Conditions: Blood Glucose; Hormones; Therapeutic Uses; Appetite

Treatments: Dietary Supplement: Lactisole

Study type: Interventional

Funder types: Other

Identifiers

NCT01121783

Lactisole

Details and patient eligibility

About

The purpose of the study is to determine whether the sweet taste receptors in the gut are involved in sensing sweet substances and controlling appetite and the amount we eat. Lactisole is a substance commonly used in food products to reduce the perceived sweetness of certain sugars and sweeteners. The aim of this study is to investigate whether the responses to a glucose solution, intragastrically administered to healthy male and female volunteers, is affected by the presence of lactisole in the gut. Understanding the mechanisms by which nutrients are initially detected in the gut and how they influence food intake is critical to the development of novel food products that could reduce food consumption.

Full description

Obesity is epidemically prevalent and a major risk factor for chronic diseases making it fundamental to understand the pathways controlling food intake. During the course of a meal and afterwards the gut and brain communicate to control how full the eater feels and thus control the amount of food eaten. The information relayed from the gut to the brain regarding ingested nutrients is of increasing importance and understanding the mechanisms by which nutrient molecules are initially detected in the gut and how they signal to the brain to influence food intake is critical to the development of novel food products that could induce fullness and reduce food consumption. Increasing our understanding of how nutrients are sensed in the gut and how this may influence subsequent food intake provides promising targets for obesity prevention and treatment. Recent discoveries have shown that sweet taste receptors similar to those located in the tongue are present in the gut. It is suggested that theses receptors are involved in the way nutrients are sensed and may play an important role in appetite control and food intake.

Enrollment: 24 estimated patients

Sex: All

Ages: 18 to 45 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Aged between 18-45 years
• BMI between 18-25kg/m2
• General good health

Exclusion criteria

• Underweight or Overweight (Body Mass Index <19 or >25 kg.m-2)
• Females who are pregnant or breastfeeding
• Currently taking medication (except females taking oral contraceptive)
• Smokers
• Currently dieting or have experienced a weight change +/- 3kg in past 6 months
• Metabolic disorders (eg. Type 2 diabetes)
• History of gastrointestinal disorders
• Participation in other research in past 3 months

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Single Blind

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24 participants in 4 patient groups, including a placebo group

Lactisole-Glucose

Active Comparator group

Lactisole-water

Active Comparator group

Treatment:

Dietary Supplement: Lactisole

Dietary Supplement: Lactisole

Dietary Supplement: Lactisole

Dietary Supplement: Lactisole

Water-Glcuose

Placebo Comparator group

Treatment:

Dietary Supplement: Lactisole

Dietary Supplement: Lactisole

Dietary Supplement: Lactisole

Dietary Supplement: Lactisole

Water-Water

Placebo Comparator group

Treatment:

Dietary Supplement: Lactisole

Dietary Supplement: Lactisole

Dietary Supplement: Lactisole

Dietary Supplement: Lactisole