The Effect of Leucine on Carnitine Transport to Skeletal Muscle (ROL)

Gdansk University of Physical Education and Sport

Status: Completed

Conditions: Muscle Loss

Treatments: Dietary Supplement: L-leucine; Dietary Supplement: L-carnitine

Study type: Interventional

Funder types: Other

Identifiers

NCT05009654

2014/15/B/NZ7/00893

NCN_ROL

Details and patient eligibility

About

The primary aim of the current research project is to explore whether leucine stimulates carnitine transport, and thus affecting muscle carnitine content.

A secondary aim of this project is to investigate the effect of carnitine with leucine supplementation on muscle strength and body composition.

Enrollment: 16 patients

Sex: All

Ages: 18 to 29 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• must be able to swallow tablets

Exclusion criteria

• cardiovascular disease
• liver disease
• kidney disease
• neuromuscular disease
• gastrointestinal disorders (including stomach ulcers and erosions)
• diabetes
• other severe chronic diseases

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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16 participants in 2 patient groups, including a placebo group

carnitine + leucine

Experimental group

Description:

1000 mg L-carnitine with 3000 mg L-leucine per day for 24 weeks

Treatment:

Dietary Supplement: L-leucine

Dietary Supplement: L-carnitine

leucine

Placebo Comparator group

Description:

4000 mg L-leucine per day for 24 weeks

Treatment:

Dietary Supplement: L-leucine