The Effect of Leukocyte and Platelet-rich Fibrin With Antimicrobial Photodynamic Therapy in Aggressive Periodontitis

Kafrelsheikh University

Status: Enrolling

Conditions: Photodynamic Therapy; Aggressive Periodontitis; L-PRF

Treatments: Procedure: antimicrobial photodynamic therapy without L-PRF; Procedure: L-PRF with antimicrobial photodynamic therapy

Study type: Interventional

Funder types: Other

Identifiers

NCT05043935

waiting

Details and patient eligibility

About

Antimicrobial photodynamic therapy (aPDT) is associated with photosensitizing agents which promote the generation of free radicals and singlet oxygen, which are cytotoxic to certain bacteria. Leukocyte and platelet-rich fibrin (L-PRF) has been used extensively in the treatment of intrabony defects and achieved excellent results. It acts as an immune regulation node with inflammation control abilities, including a slow continuous release of growth factors which stimulates periodontal regeneration. The aim of this study is to evaluate the adjunctive effects of aPDT with and without L-PRF in aggressive periodontitis patients.

Enrollment: 20 estimated patients

Sex: All

Ages: 18 to 40 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• systemically healthy
• non- smoker,
• not received any periodontal treatment within the last 6 months,
• no antibiotics, anti- inflammatory drugs or any other medication taken within the last 6 months

Exclusion criteria

• any systemic disease that might influence the prognosis of periodontal disease and outcome of the treatment,
• any medical condition that required antibiotic prophylaxis before the treatment,
• smoking,
• pregnancy and lactation,
• ingestion of antibiotics, anti-inflammatory drugs or any other medication during the study period,
• any physical limitations or restrictions that might preclude normal oral hygiene procedures.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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20 participants in 2 patient groups

L-PRF with antimicrobial photodynamic therapy

Experimental group

Description:

Application of L-PRF with antimicrobial photodynamic therapy in the defect

Treatment:

Procedure: L-PRF with antimicrobial photodynamic therapy

antimicrobial photodynamic therapy

Active Comparator group

Description:

Application antimicrobial photodynamic therapy in the defect

Treatment:

Procedure: antimicrobial photodynamic therapy without L-PRF