The Effect of Locally Delivered Ciclosporin as an Adjunct to Healing After Treatment of Periodontal Pockets

PerioC

Status and phase

Completed

Phase 2

Conditions

Periodontitis

Treatments

Drug: Ciclosporin

Study type

Interventional

Funder types

Industry

Identifiers

NCT02366585

PERIOC_CTP001

Details and patient eligibility

About

The main purpose of the trial is to investigate the effect of locally delivered ciclosporin as an adjunct to non-surgical mechanical debridement in the treatment of chronic periodontitis and to compare it to mechanical debridement alone.

Enrollment

23 patients

Sex

All

Ages

30+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Patients in good general health
2 pairs of contralateral interproximal periodontal sites with probing depths of ≥7mm in single-rooted teeth not associated with furcations or root furrows.The test sites should have a distance of at least two teeth to the control sites.
Teeth selected should have a vital pulp as determined by thermal or electric stimulation

Exclusion criteria

Patients already included in other clinical trials involving therapeutic intervention (either medical or dental)
Periodontal treatment during the last 6 months
Antibiotic treatment 6 months prior to the start of the trial
Antibiotic prophylaxis required for dental treatment
Patients with acute infectious lesions in the areas of intended treatment
Regular anti-inflammatory medication
Known history of ciclosporin allergy
Ongoing medication that may affect the clinical features of periodontitis
Patients who are smokers
Patients that are immuno-compromized or on immunosuppressive medication
Patients who are pregnant or lactating