The Effect of Long Term Therapy With High Flow Humidification Compared to Usual Care in Patients With Bronchiectasis (BX)

Dr. Giuseppe Fiorentino

Status: Unknown

Conditions: Bronchiectasis Adult; Lung Infection; Quality of Life; Humidifier Lung; COPD Asthma; COPD Exacerbation

Treatments: Device: High Flow Humidification

Study type: Interventional

Funder types: Other

Identifiers

NCT04142827

High Flow in Bronchiectasis

Details and patient eligibility

About

The study is intended to understand the benefit of Long Term Home care Therapy with nasal High flow in Bronchiectasis patients at home. Primary end point is to evaluate daily life compared to usual care and secondary is to evaluate the changes in lung function

Enrollment: 160 estimated patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• Diagnosis of Bronchiectasis on HRCT
• Optimization of Therapy for at least 15 days before enrollment
• Autonomous patients with possibilities of practicing rehabilitations cycles

Exclusion criteria

• OSAS (ODI>10/h)
• HOME NIV
• PH<7,35 - paO2< 60mmHg, paCo2> 55 mmHg
• Lung cancer
• Contraindication to high-flow nasal cannula (hfnc)

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Single Blind

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160 participants in 2 patient groups

Therapy with high flow humidification

Experimental group

Description:

The patients will be activated after enrollment with myAirvo2 device at home for 6 months before first observations

Treatment:

Device: High Flow Humidification

Therapy with usual care

No Intervention group

Description:

The patients will be under usual care for observational