The Effect of Losartan on the Recoverability of Renal Function in Anuric and Oliguric Patients With Unilateral Obstructed Kidney

Mansoura University

Status: Completed

Conditions: Uropathy Obstructive; Uropathy; Losartan Adverse Reaction

Treatments: Drug: Placebo; Drug: Cozaar (Losartan Potassium 25mg)

Study type: Interventional

Funder types: Other

Identifiers

NCT04278495

LOSARTAN.OBST.UROPATHY

Details and patient eligibility

About

Previous experimental studies concluded that angiotensin receptor blockers can ameliorate the harmful inflammatory and histological changes after relief of obstruction. Nevertheless, these witnessed effects have not been yet translated into the clinical practice.

Enrollment: 96 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• anuric and oliguric patients
• calculuar ureteral obstruction

Exclusion criteria

• anomalous kidney
• bilateral obstructed kidney
• history of recent use of angiotensin receptor blockers or angiotensin-converting enzyme inhibitors
• ASA score of >3

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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96 participants in 2 patient groups, including a placebo group

Losartan

Active Comparator group

Description:

to receive the medication Cozaar (Losartan Potassium 25mg "Merck Sharp \& Dohme-UK"),

Treatment:

Drug: Cozaar (Losartan Potassium 25mg)

Placebo

Placebo Comparator group

Description:

to receive either placebo

Treatment:

Drug: Placebo