The Effect of Lower Urinary Tract Electrical Stimulation on Renal Urine Production (diuresis) (EFFLUENT)

University of Zurich (UZH)

Status: Withdrawn

Conditions: Diuresis Under Eletrical Stimulation

Treatments: Other: electrical stimulation (non painful) of the lower urinary tract to determine the current perception threshold and record sensory evoked potentials

Study type: Interventional

Funder types: Other

Identifiers

NCT03256656

2016-01695

Details and patient eligibility

About

In previous studies, in which the perception threshold and / or sensory evoked potentials at different points of the lower urinary tract were examined and measured by means of electrical stimulation, a clear increase in the volume of the bladder and thus the urine excretion under the stimulation could be observed. This observation is now to be investigated more closely in a separate study, in order to strengthen the observation with further measured data and to find possible physiological connections. A detectable influence of electrical stimulation in the lower urinary tract on renal urine production would have a significant relevance both therapeutically and for the neurophysiological understanding of interactions between the lower and upper urinary tracts.

Sex: All

Ages: 18 to 60 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

Healthy volunteers:

• Written informed consent
• Good mental and physical health
• Age >18 years

Patients with SCI:

• Written informed consent
• Good mental condition
• Age >18 years
• Complete spinal cord injury (AIS A)

Exclusion criteria

Healthy volunteers:

• Any neurological or urological pathology
• Pregnancy or breast feeding
• Urinary tract infection (UTI), frequent UTIs
• Hematuria
• Any previous pelvic or spine surgery
• Any craniocerebral surgery
• Any anatomical anomaly of the LUT or genitalia
• Any metabolic disease
• Any renal disease
• Any urinary tract malignancy
• Bladder capacity <150mL or strong desire to void (SDV) already at 60mL

Patients with SCI:

• Any urinary tract malignancy
• Any anatomical anomaly of the LUT or genitalia
• Pregnancy or breast feeding
• Urinary tract infection (UTI), frequent UTIs
• Hematuria
• Any metabolic disease
• Any renal disease

Trial design

0 participants in 2 patient groups

Healthy subjects

Experimental group

Treatment:

Other: electrical stimulation (non painful) of the lower urinary tract to determine the current perception threshold and record sensory evoked potentials

Patients with SCI

Active Comparator group

Treatment:

Other: electrical stimulation (non painful) of the lower urinary tract to determine the current perception threshold and record sensory evoked potentials