The Effect of Lt to Rt Shunt Using Veno-veno-arterial Extracorporeal Membrane Oxygenation (ECMO) on Coronary Oxygenation in Lung Transplantation Patients

Yonsei University

Status: Completed

Conditions: Interstitial Pulmonary Fibrosis ARDS; Bronchiectasis; COPD (Chronic Obstructive Pulmonary Disease); ARDS (Acute Respiratory Distress Syndrome); Lymphangioleiomyomatosis; Primary Pulmonary Hypertension

Treatments: Procedure: Veno-veno-arterial ECMO

Study type: Interventional

Funder types: Other

Identifiers

NCT02859194

4-2016-0124

Details and patient eligibility

About

ECMO(Extracorporeal membrane oxygenation) is being essential for cardiopulmonary failure patients. There are two types of ECMO, which is veno-veno (V-V) that can be used in respiratory failure patients and veno-arterial (V-A) that can be used in cardiac failure patients. V-A ECMO can also be used during lung transplantation, substitution of cardiopulmonary bypass, which can show sufficient performance during operation and better postoperative outcome. However, regarding V-A ECMO circulating from femoral vein to femoral artery, there is a pro blem of differential hypoxia which might influence coronary artery and head vessels. In this prospective study, the investigators are planning to put another ECMO catheter into internal jugular vein which takes a role of left to right shunt, to mitigate the hypoxia of coronary artery.

Enrollment: 10 patients

Sex: All

Ages: 20 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. scheduled for double lung transplantation

Exclusion criteria

1. patients who have history of coronary artery occlusive disease
2. patients with arrhythmia

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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10 participants in 1 patient group

Veno-veno-arterial ECMO group

Experimental group

Treatment:

Procedure: Veno-veno-arterial ECMO