The Effect of Magnesium Supplementation During General Anesthesia on the Quality of Postoperative Recovery in Children

Seoul National University

Status: Completed

Conditions: Emergence Delirium

Treatments: Drug: Saline; Drug: Magnesium

Study type: Interventional

Funder types: Other

Identifiers

NCT03132701

H1703-110-840

Details and patient eligibility

About

Evaluation of prevention of emergence delirium and analgesic effect of magnesium on children

Full description

Children < 8 years old who scheduled for elective opthalmic surgery are randomly assigned to Magnesium (Mg) group and control group. Before anesthetic induction, modified Yale Preoperative Anxiety Scale (m-YPAS) is assessed. Routine anesthetic induction is performed, and neuromuscular blocker is not used. Laryngeal mask airway is inserted and controlled ventilation is started.

In Mg group, Mg of 30 mg/kg is administered for 10 minutes and then continuously infused (10mg/kg/hr) until 5 minutes before surgery end. In control group, the similar volume of saline is infused.

Pediatric Anesthesia Emergence Delirium (PAED) scale and pain score (Modified Children's Hospital of Eastern Ontario Pain Scale, CHEOPS) will be measured immediately after and 30 minutes after surgery.

Enrollment: 66 patients

Sex: All

Ages: 2 to 7 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Children aged between 2 and 7 years
• American Society of Anesthesiologist physical status 1 and 2
• Children scheduled for opthalmic surgery

Exclusion criteria

• Allergy history to any drugs
• Risk of malignant hyperthermia
• Neuromuscular disease
• With arrhythmia
• Any pulmonary, cardiac, hepatic and renal disease
• Obesity

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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66 participants in 2 patient groups, including a placebo group

Magnesium group

Active Comparator group

Description:

Mg is administered with dose of 30 mg/kg for 10 minutes and then 10 mg/kg/hr until 5 minutes before surgery ends

Treatment:

Drug: Magnesium

Control group

Placebo Comparator group

Description:

Saline is administered with same volume of Mg of magnesium group until 5 minutes before surgery ends

Treatment:

Drug: Saline