The Effect of Manipulating Hydration Status During Cycling in the Heat on Acute Kidney Injury Biomarkers

Loughborough University

Status: Completed

Conditions: Hypohydrated; Euhydrated

Treatments: Other: Water intake

Study type: Interventional

Funder types: Other

Identifiers

NCT04140045

R19-P130

Details and patient eligibility

About

Acute Kidney Injury (AKI) is common in prolonged endurance events. Risk factors for exercise-associated AKI include: the exercise itself, heat, hypohydration, muscle breakdown and non-steroidal anti-inflammatory drug (NSAID) use. Prior research from our laboratory showed the hypohydration during high-intensity running increased a biomarker of AKI (urine osmolality-corrected kidney injury molecule 1). Therefore, the current study will now investigate the effect of manipulating hydration status during cycling on biomarkers of AKI.

Enrollment: 14 patients

Sex: Male

Ages: 18 to 50 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy
• recreationally active

Exclusion criteria

• Smoker/vaper
• regular use of anti-inflammatory medications (e.g. ibuprofen)
• history of kidney disease or diabetes

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: None (Open label)

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14 participants in 2 patient groups

Hypohydrated

Experimental group

Description:

Participants will be required to restrict their water intake during cycling in the heat (90-120 minutes at 35°C), in order to achieve a body mass loss of approximately 3%.

Treatment:

Other: Water intake

Euhydrated

Experimental group

Description:

Participants will be provided with water intake that matches their sweat losses during cycling in the heat (90-120 minutes at 35°C)

Treatment:

Other: Water intake