The Effect of Melatonin Application Following Removal of Impacted Third Molar

Fayoum University

Status and phase: Completed; Phase 3

Conditions: Impacted Third Molar Tooth

Treatments: Drug: Placebo; Drug: 3 mg melatonin

Study type: Interventional

Funder types: Other

Identifiers

NCT04424875

Melatonin and 3rd molar

Details and patient eligibility

About

In the present study, the main hypothesis hypothesizes that the local application of melatonin in the post-extraction socket produces favorable differences in the immediate postoperative period, as anti-inflammatory, analgesic, and early osteogenic regarding the natural healing process of the socket.

Enrollment: 38 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age ≥18ys
• no systemic disease
• impacted mandibular third molar class II position B on Pell- Gregory classification

Exclusion criteria

• history of metabolic or systemic diseases affecting bone or healing process,
• local infection,
• tobacco use,
• oral contraceptive,
• pregnancy and lactation
• patients who had taken analgesics or anti-inflammatories for 1 week prior to enrollment in the study

Trial design

Primary purpose: Supportive Care

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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38 participants in 2 patient groups, including a placebo group

study arm

Experimental group

Description:

patients will undergo surgery to remove impacted lower third molar and receive Melatonin (3 mg melatonin into 2 ml hydroxyethyl cellulose gel 2%) in the socket following removal of the impacted third molar

Treatment:

Drug: 3 mg melatonin

controlled arm

Placebo Comparator group

Description:

patients will undergo surgery to remove impacted lower third molar and patients will receive no melatonin (2 ml of hydroxyethyl cellulose gel 2 %).

Treatment:

Drug: Placebo