The Effect of Menstrual Cycle Phase on Muscle Protein Synthesis

U

University of Exeter

Status

Enrolling

Conditions

Menstrual Cycle Phase
Muscle Protein Synthesis

Treatments

Other: Phase of the menstrual cycle

Study type

Interventional

Funder types

Other

Identifiers

NCT06268678
4539513

Details and patient eligibility

About

The combination of dietary protein ingestion and resistance exercise are essential to increase muscle protein synthesis. The vast majority of studies assessing protein intake following resistance exercise in young adults has been conducted exclusively in men or in studies where both men and women are assessed. The increase in muscle mass is thought to be impacted by sex hormones that fluctuate across different phases of the menstrual cycle. However, the effect of menstrual cycle phase on muscle protein synthesis following exercise is not known.

Enrollment

15 estimated patients

Sex

Female

Ages

18 to 40 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

* Female, aged 18-40 years * BMI between 18 and 30 kg/m2 * Recreationally active * Regular menstrual cycle

Exclusion criteria

* Smoking or use of tobacco containing products * Irregular menstrual cycle * Currently on any form of hormonal contraception * Post-menopausal * Pregnant or breastfeeding * Diagnosed metabolic/pulmonary/musculoskeletal illness * Diagnosed cardiovascular disease or hypertension * Use of medications that may impact protein metabolism or are anti-inflammatory * Gastrointestinal disorders * Allergy to pomegranate or amino acids * Injuries that would impact ability to complete study

Trial design

Primary purpose

Basic Science

Allocation

Randomized

Interventional model

Crossover Assignment

Masking

None (Open label)

15 participants in 2 patient groups

Follicular
Experimental group
Description:
Follicular phase assessment of muscle protein synthesis.
Treatment:
Other: Phase of the menstrual cycle
Luteal
Experimental group
Description:
Luteal phase assessment of muscle protein synthesis
Treatment:
Other: Phase of the menstrual cycle

Trial contacts and locations

1

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Central trial contact

Marianna Apicella

Data sourced from clinicaltrials.gov

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