The Effect of Metformin on the Correlation Between Hyperinsulinemia and Hypertension

China-Japan Friendship Hospital

Status: Completed

Conditions: Diabetes Mellitus; Essential Hypertension

Treatments: Drug: Metformin; Drug: Fosinopril

Study type: Interventional

Funder types: Other

Identifiers

NCT01342614

MET140

Details and patient eligibility

About

The objective of this study is to investigate the effect of metformin on the correlation between hyperinsulinemia and hypertension.

Enrollment: 140 patients

Sex: All

Ages: 20 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:

• 20 to 65 years of age, regardless of sex
• duration of hypertension was <5 years
• overweight or obesity, mild to moderate hypertension, receive no euglycemic agent or antiobesity drug

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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140 participants in 2 patient groups

Fosinopril group

Active Comparator group

Description:

Fosinopril group received fosinopril, 10mg, once per day.

Treatment:

Drug: Fosinopril

Metformin group

Experimental group

Description:

Metformin group was treated with metformin hydrochloride, 500mg, three times per day

Treatment:

Drug: Metformin