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The Effect of Methylphenidate on Decision-making Ability of Attention Deficit Hyperactivity Disorder (ADHD) Adults

S

Shalvata Mental Health Center

Status and phase

Completed
Phase 1

Conditions

Attention Deficit Hyperactivity Disorder

Treatments

Dietary Supplement: sweetener pill
Drug: methylphenidate

Study type

Interventional

Funder types

Other

Identifiers

NCT01040702
SH-40107

Details and patient eligibility

About

The aim of the study is to assess the effect of Methylphenidate on cognitive performance and decision-making ability of ADHD adults, and to compare this effect to the effect on healthy control adults.

Full description

Two matched groups of adults - with and without ADHD diagnosis - will perform a battery of computerized tasks assessing sustained attention,working-memory,non-verbal IQ,and decision-making ability. In each group,half of the participants will perform the tasks after receiving a capsule containing methylphenidate (MPH), and the other half will perform the tasks after receiving placebo. Task performance measures will then be compared in order to assess the effect of MPH on these domains.

Enrollment

58 patients

Sex

All

Ages

21 to 50 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • adults in the age of 21-50

Exclusion criteria

  • pregnant or nursing women.
  • people who suffer from a psychiatric disorder other than ADHD which could account for their inattention symptoms better than ADHD.
  • people who lack judgment or are unable to communicate with the experimenters.
  • people who are incapable of performing the computerized tasks due to sensory or motor disabilities.

Trial design

Primary purpose

Basic Science

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

Double Blind

58 participants in 4 patient groups, including a placebo group

ADHD -MPH
Experimental group
Description:
adults with ADHD diagnosis who receive a single dose of Methylphenidate
Treatment:
Drug: methylphenidate
ADHD-placebo
Placebo Comparator group
Description:
adults with ADHD diagnosis who received placebo
Treatment:
Dietary Supplement: sweetener pill
non-ADHD-MPH
Experimental group
Description:
healthy adults who received a single dose of Methylphenidate
Treatment:
Drug: methylphenidate
non-ADHD-placebo
Placebo Comparator group
Description:
healthy adults who received placebo
Treatment:
Dietary Supplement: sweetener pill

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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