The Effect of Methylphenidate on Decision-making Ability of Attention Deficit Hyperactivity Disorder (ADHD) Adults

Shalvata Mental Health Center

Status and phase: Completed; Phase 1

Conditions: Attention Deficit Hyperactivity Disorder

Treatments: Dietary Supplement: sweetener pill; Drug: methylphenidate

Study type: Interventional

Funder types: Other

Identifiers

NCT01040702

SH-40107

Details and patient eligibility

About

The aim of the study is to assess the effect of Methylphenidate on cognitive performance and decision-making ability of ADHD adults, and to compare this effect to the effect on healthy control adults.

Full description

Two matched groups of adults - with and without ADHD diagnosis - will perform a battery of computerized tasks assessing sustained attention,working-memory,non-verbal IQ,and decision-making ability. In each group,half of the participants will perform the tasks after receiving a capsule containing methylphenidate (MPH), and the other half will perform the tasks after receiving placebo. Task performance measures will then be compared in order to assess the effect of MPH on these domains.

Enrollment: 58 patients

Sex: All

Ages: 21 to 50 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• adults in the age of 21-50

Exclusion criteria

• pregnant or nursing women.
• people who suffer from a psychiatric disorder other than ADHD which could account for their inattention symptoms better than ADHD.
• people who lack judgment or are unable to communicate with the experimenters.
• people who are incapable of performing the computerized tasks due to sensory or motor disabilities.

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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58 participants in 4 patient groups, including a placebo group

ADHD -MPH

Experimental group

Description:

adults with ADHD diagnosis who receive a single dose of Methylphenidate

Treatment:

Drug: methylphenidate

ADHD-placebo

Placebo Comparator group

Description:

adults with ADHD diagnosis who received placebo

Treatment:

Dietary Supplement: sweetener pill

non-ADHD-MPH

Experimental group

Description:

healthy adults who received a single dose of Methylphenidate

Treatment:

Drug: methylphenidate

non-ADHD-placebo

Placebo Comparator group

Description:

healthy adults who received placebo

Treatment:

Dietary Supplement: sweetener pill